Mengdi Han Research Group(韩梦迪课题组)BioE Radar

BioE Radar Beta

Weekly updates: Friday 03:30 Beijing / Thursday 15:30 New York / Thursday 19:30 London

Journals included

52 selected articles

2026-10-16 03:30 – 2026-10-23 03:30 (Beijing time)

ACS Nano

Nanoedge-Regulated Impedance Sensing for Sensitive Cardiomyocyte Mechanophysiological Investigation and Functional Drug Assessment

Chengyun Wang, Jiaru Fang, Hao Wang, Zhekun Jia, Tao Liang, Dongxin Xu, Ning Hu, Zhen Wang

Nanoedge-regulated impedance sensing tracks cardiomyocyte mechanophysiology and supports functional drug assessment. The approach links cellular mechanical states to continuous electrical readout. The approach may help connect a cell-level electrical measurement to changes in mechanical function when screening biological responses to a treatment.

Mechanics & resonators / Bioelectronics

ACS Nano

Nanomesh Bioelectronics Inspired by Basement Membrane for In Situ Monitoring of Oxidative Stress at the Alveolar-Capillary Barrier

Yi Zhao, Wen-Ting Fan, Meng-Yuan Sun, Yu-Jun Zhang, Rong-Rong Xiao, Wei-Hua Huang, Yan-Ling Liu

Basement-membrane-inspired nanomesh bioelectronics monitor oxidative stress at the alveolar–capillary barrier. The ultrathin interface offers a reference for conformal bioelectronics and local chemical sensing. The conformal interface may offer ideas for placing electrochemical sensing close to a biological barrier while limiting the mechanical burden of the sensor.

Bioelectronics / Longitudinal physiology

Advanced Functional Materials

A Starfish‐Inspired Hierarchical Multimodal Flexible Sensor for Decoupled Thumb Motion Perception and Virtual Human–Machine Interaction

Lu Liu, Zengbai Ouyang, Mengze Zhang, Jiantao Yao, Xiaoli Jia, Peng Zhang, Bo Han, Yu Gu, Yundou Xu

A starfish-inspired sensor separates radial strain channels from isolated pressure nodes to decouple global deformation and local touch. The study reports 99.27% test accuracy for six thumb motions, with relevance to wearable human–machine interfaces. The mechanical separation of sensing regions may inform designs that need to distinguish distributed deformation from contact at a particular location.

Wearables & e-skins

Advanced Healthcare Materials

A Standardized Chewable Conductive Hydrogel Sensor for Direct Monitoring of Masticatory Dynamics

Xiaoxuan Xue, Zhan Gao, Jun Wang, Yizhang Yang, Kewei Zhang, Chao Yang

A standardized chewable conductive-hydrogel sensor directly records masticatory dynamics. It provides a reference for intraoral mechanical monitoring and durable soft sensing interfaces. The chewable form factor may offer ideas for placing a mechanical sensor at the point of oral loading, where the interface must accommodate repeated contact and deformation.

Wearables & e-skins / Mechanics & resonators

Advanced Materials

Biodegradable Capacitive‐Coupling Bioelectronics for Wireless Electrical Stimulation and Longitudinal Electrophysiological Monitoring of Peripheral Nerve Regeneration

Yunjie Jin, Renyuan Sun, Wenliang Liu, Xianzhen Dong, Yiru Yang, Shicong Chen, Chunlin Wen, Kun Yang, Weilin Xu, Chao Xu, Zhiqiang Luo, Hongjun Yang

Biodegradable capacitive-coupling bioelectronics combine wireless electrical stimulation, nerve guidance and longitudinal compound-action-potential recording. A rat sciatic-nerve model demonstrates recovery trends consistent with wired electrophysiology, with relevance to resorbable implants and external coupling. The integration of intervention and electrophysiological follow-up may inform temporary nerve interfaces that need to track recovery as well as deliver stimulation.

Wireless implants / Bioelectronics / Longitudinal physiology

Journal of Micromechanics and Microengineering

Property-level analysis of environment-dependent piezoelectric resonant microcantilever mass sensors: Multi-metric sensitivity and Pareto screening

Reza Ghaderi

An analysis of 25 piezoelectric microcantilever material combinations compares performance in air and water. Reported AlN–SiC sensitivities are 1.10 and 0.025 Hz pg⁻¹, respectively; Sobol and Pareto analyses show that material selection depends on the medium and readout metric. The comparison highlights why a resonant material that performs well in air may not remain optimal in liquid, which is relevant to fluid-loaded implantable sensors.

Mechanics & resonators / Methods & fabrication

Microsystems & Nanoengineering

Focusing and weighing microanalytes in liquid enabled by higher-order piezoelectric resonant membranes

Jingui Qian, Wenqi Fan, Sheng Tang, Cheng Guo, Xiangyang Wang, Mengyu Huang, Guoqiang Wu, Joshua E.-Y. Lee

Higher-order piezoelectric resonant membranes focus particles in droplets near regions of maximum vibration and then weigh them by resonance. The integrated actuation–sensing platform is relevant to liquid-phase mass sensing, fluid damping and mechanical biochemical readout. Using resonant motion for both particle positioning and measurement may inform systems where analyte location would otherwise complicate interpretation of a liquid-phase signal.

Mechanics & resonators / Methods & fabrication

Microsystems & Nanoengineering

Towards advanced motion control systems for micro-scale magnetic drillers inside viscoelastic media

Emmett Z. Freeman, Pranjal Chatterjee, Tony H. Wang, Kimberly Hoang, Azadeh Ansari

An eight-solenoid field generator controls 250 × 250 × 1,250 μm magnetic microdrillers within a 20 × 20 × 20 cm³ workspace. In 0.6 wt% agarose, the study reports speeds up to 155 μm s⁻¹ and steering errors below 3°, with relevance to actuation in viscoelastic media. The combination of field generation and trajectory control may inform the design of magnetic actuation systems in soft media; the reported accuracy applies to the demonstrated agarose setting.

Magnetic systems / Mechanics & resonators

Nano Letters

Flexible Microlaser Emitter for Mechanical Sensing and Pulse Mapping

Ningyuan Nie, Zhiyi Yuan, Tian Zhou, Guocheng Fang, Bowen Fu, Xiyu Sun, Po-Hao Tseng, Yu-Cheng Chen

A flexible microlaser emitter supports mechanical sensing and pulse mapping. The optical readout offers a complementary route to flexible biomechanical monitoring. The potential relevance is a mechanical measurement encoded in an optical emitter, offering a comparison point for sensor architectures that use electrical or magnetic readout.

Wearables & e-skins / Mechanics & resonators

Nature

Cortex-wide imaging in naturally behaving mice with 1-gram wireless mesoscopes

Yuanlong Zhang, Angran Li, Lekang Yuan, Mingrui Wang, Weihao Zhao, Zhenbo Wang, Boyang Zang, Yangxuan Zhou, Tao Yu, Lin Gao, Yu Wu, Rongkang Zhu, Mengyi Tian, Kun Li, Jiamin Wu, Pu Dai, Qionghai Dai

The 1.0 g Airscope records more than 8,500 neurons per animal across a 6 mm field of view at 12.5 Hz. Demonstrations include swimming and simultaneous recordings from multiple animals or brain and spinal cord, with relevance to monitoring during natural behaviour. The combination of low mass and broad spatial coverage may inform trade-offs between recording extent, payload and freedom of movement in wearable neural instrumentation.

Wireless implants / Longitudinal physiology

Nature

Touch-sensing digital pixel fibre enables interactive garment GUI

Heng Fu, Ziang Li, Swetika Chaturvedi, Xiaoyu Zhang, Xiaolong Li, Qianyi Li, Tural Khudiyev

Digital pixel fibres integrate display, touch localization, computation and multimodal input/output. A sleeve prototype provides 96 × 54 pixels at 30 fps with 8-bit colour, alongside flexibility, breathability and washability. The integration may provide a useful reference for wearable systems that need both user input and feedback within the same fabric, rather than separate rigid interface modules.

Wearables & e-skins

Nature Communications

Regenerable, closed-loop, nonenzymatic continuous glucose monitoring enabled by in situ electrochemical interfacial alkalinization

Qiang Zeng, Liangjun Xia, Junyao Gong, Jieyao Qin, Sijie Zhou, Zhuan Fu, Jiajing Zhang, Ke Lin, Chunhua Zhang, Wei Zhang, Weilin Xu

A wrist-worn hollow-microneedle system extracts interstitial fluid and uses electrochemical interfacial alkalinization for nonenzymatic glucose measurement. Demonstrations include quasi-continuous monitoring in rats and an initial test in one person. A removable sensor cartridge addresses maintenance of the skin interface. The separation between the skin-access interface and a replaceable sensing cartridge may be useful when considering maintenance and repeat measurements in wearable chemical monitoring.

Wearables & e-skins / Bioelectronics / Longitudinal physiology

Nature Machine Intelligence

Large-scale iontronic skins with neural-hierarchical processing architecture

Zhibin Li, Bingxu Da, Junli Shi, Taihong Wang, Wenlong Si, Bowen Li, Hanxiang He, Zelong Liao, Tianyu Wu, Xudong Han, Longyi Bai, He Kong, Chaoyang Song, Chuan Fei Guo

A hierarchical iontronic skin combines more than 10,000 sensing units, a density of 1,110 units cm⁻² and parallel readout at 100 fps. Frequency-position encoding and hierarchical compression address crosstalk and bandwidth; a robot resolves 300 μm surface features. This architecture may inform tactile-array designs where the main challenge is transmitting and processing many sensing channels while preserving spatial detail.

Wearables & e-skins

Nature Materials

Bioresorbable metal-free molecular magnets enable untethered organ monitoring

Yizhang Wu, Zhang Yue, Sicheng Xing, Dingyi Yang, Jie Wang, Yihan Liu, Harrison Cohen, Lucy Liu, Qizhang Jiao, Zifeng Li, Hanad Ali, Chaya Perera, Torsten Peter Vahl, Lauren Sharan Ranard, Zhibo Zhang, Andrew J. Einstein, Anran Zhang, Stephen Dashnaw, Yiwen Huang, William Pak, Ziheng Guo, Gongkai Yuan, Siyuan Liu, Alexander Romanov, Sen Yang, X. S. Wu, Yong Wang, Ke Cheng, Wubin Bai

Bioresorbable metal-free molecular magnets based on modified graphitic carbon nitride are integrated into epicardial patches or injectable hydrogels. External Hall arrays support organ readout with motion-artifact suppression; a porcine study tracks ejection fraction over four weeks. The material and readout approach is relevant to resorbable magnetic implants. The combination of a resorbable magnetic material and external field readout may inform temporary organ-monitoring systems; translation to other organs would require separate validation.

Magnetic systems

Research Square - Nature Portfolio

A single-wire, large-area, super-resolution electromagnetic skin enabling human-level spatial acuity

Arindam Basu, Gaishan Li, Jiachen Du, Yiqing Sun, Shuai Dong, Chiara Bartolozzi, Geng-Bo Wu

A meandering spoof surface plasmon polariton transmission line combines frequency-diverse sensing with neural reconstruction to localize touch using a single wire. The authors report a super-resolution factor above 10,000 across skin areas of 2,500–28,800 mm², with demonstrations in dynamic touch and object recognition. The architecture is relevant to reducing wiring in large-area tactile interfaces. Preprint; not peer reviewed. The single-wire architecture may offer an alternative to dense point-to-point connections when scaling tactile coverage, although adapting it to another surface would require recalibration.

Wearables & e-skins / Bioelectronics

Research Square - Nature Portfolio

Overcoming conventional trade-offs in strain sensing with physics-guided inverse design of aperiodic architected nanocomposites

Francisco Molina-Lopez, Viktor Naenen, Stijn De Smedt, Altynay Kaidarova, Ruth Cardinaels

Physics-guided inverse design arranges printed carbon-nanotube/PDMS cells into aperiodic strain-sensing architectures. One design achieves a gauge factor of 1.55 with R² above 0.98 over 30% strain, improving sensitivity relative to its most linear constituent. Respiratory monitoring illustrates a wearable application. The method offers a route to tailoring sensor response through architecture rather than filler composition alone. Preprint; not peer reviewed. The result may help frame sensor optimization as a spatial design problem, making it useful for studies that need a predictable response across an extended deformation range.

Wearables & e-skins / Methods & fabrication

Science

Wireless electrocatalytic closed-loop system for drug-free management of diabesity

Debasis Maity, Preetam Guha Ray, Peter Buchmann, Ghislaine Charpin-El Hamri, Martin Fussenegger

The wireless ECHO implant uses electrocatalysis for glucose control and can interface with a commercial continuous glucose monitor. The study reports glucose normalization within 1 h in diabetic mice and six weeks of treatment. Its closed-loop architecture offers a reference for wireless therapeutic systems. The combination of sensing and electrocatalytic intervention may help frame design choices for autonomous implantable therapy; the reported efficacy remains evidence from mice.

Wireless implants / Bioelectronics

Science Advances

Local control of Cre-regulated genetic modeling in vivo using wireless implantable optoelectronics

Trisha Bansal, Min-Kyu Lee, Courtney Coleman, Young-Mee Kim, Dane Hintermueller, Yaner Chen, Varsha Sreekanth, Chad R. Haney, Olga A. Karginova, Raudel Avila, Jacob Matsche, Shaluah Vijeth, Farah Yousef, Kento Yamagishi, Jiheon Kang, Kaitlyn Mowry, Minsung Kim, Sophianne Loh, Sachin Clark, Huong Huynh, Youngdo Kim, Kaiqing Zhang, Haohui Zhang, Shupeng Li, Yuanting Wei, Steve Seung-Young Lee, Yuru Liu, Anthony R. Banks, Odile David, Peter T. Toth, Yonggang Huang, Ameen Salahudeen, Cameron H. Good, Jalees Rehman, John A. Rogers, Andrei V. Karginov

Wireless implantable optoelectronics provide local control of Cre-regulated genetic models in vivo. Device miniaturization, wireless power and local stimulation are relevant to battery-free implantable systems. The combination of wireless actuation and spatially localized optical delivery may guide implant layouts when the target response must remain confined to a selected tissue region.

Wireless implants / Bioelectronics

Science Advances

Magnetically gated millimeter-scale capsule power system for leadless electrotherapy

Feiyao Yang, Yu Tian, Enyi Zhang, Lixue Yang, Ziyue You, Puguang Peng, Han Qian, Yan Du, Haiwei Li, Yongquan Wu, Houfang Liu, Anfu Zhou, Tian-Ling Ren, Weiping Sun, Zhong Lin Wang, Di Wei

A millimetre-scale capsule uses a reed switch for magnetically gated power delivery and demonstrates cardiac pacing in large animals. The system offers an approach to leadless electrotherapy and externally triggered implants. The magnetic gate provides a design reference for externally controlling when an implanted stimulation system delivers power, rather than relying on a continuously active link.

Wireless implants

Science Advances

Magneto-mechano-electrochemical fiber for deformation-resilient and smart electronic textiles

Xiao Xiao, Chang Liu, Zimo Wang, Xiao Xiao, He Wang, Chengyue Lu, Xinru Wu, Junyi Yin, Xiao Li, Wei Zhang, Gang Ge, Wenbo Ding, Guangmin Zhou, Patrick Chia, Lei Shen, Chun Zhang, Zhiqun Lin, Yiliang Lin, Benjamin C. K. Tee, John S. Ho, Zhuangjian Liu, Ghim Wei Ho, Changsheng Wu

A magneto-mechano-electrochemical fibre regulates ion transport and combines motion-energy harvesting with magnetoelastic sensing. In its undeformed state, the study reports battery-lifetime and capacity increases of (374 ± 79)% and (61 ± 20)%, respectively, at 1.0 A g⁻¹. The coupling between deformation, ion transport and electrical behavior may inform multifunctional fibres; the quoted battery improvements should be interpreted under the reported test conditions.

Magnetic systems / Wearables & e-skins

arXiv · Applied Physics

Leaky-Wave Antenna for Non-Invasive Continuous Glucose Monitoring

Huan Wang, Han Xiao, Yi Zhang, Zhi Hua Ren, Yang Gao

This preprint uses fixed-frequency phase measurements from a leaky-wave antenna to estimate glucose-dependent dielectric changes. Tests in two participants report correlations of 0.939 and 0.906 against reference glucose values. This is an early proof of concept and has not been peer reviewed. The phase-based approach may inform electromagnetic readout design, but the very small participant sample cannot establish general clinical accuracy or robust glucose specificity.

Wearables & e-skins / Bioelectronics / Longitudinal physiology

bioRxiv · Bioengineering

Ultra-high-efficacy Wireless Neuromodulation Using a Conductive Ring Interface

Tian, J., Chen, S., Shotbolt, M., Nandakumar, B., Andre, V., Abdel-Mottaleb, M., Zhu, E., Liang, P., Zhang, E., Ganzer, P., Khizroev, S.

This theoretical and COMSOL preprint proposes a conductive-ring implant for magnetic neuromodulation. At 10 kHz and 1 kA m⁻¹, the model predicts a local field of ~50 V m⁻¹ across a gap. Experimental validation is still required; the work has not been peer reviewed. The conductive-ring geometry may offer a way to explore local field enhancement near an implant; the simulated field should not be treated as demonstrated neural activation.

Wireless implants / Magnetic systems

npj Flexible Electronics

Multiplexed sensor arrays for high-spatiotemporal decoding of complex physiological networks

Jinze Li, Hongcheng Gu, Huicheng Ouyang, Yijun Guo, Zhongze Gu

This review compares temporal, frequency, spatial, optical, code and hybrid multiplexing. It discusses signal integrity, calibration, materials, mechanics, power and data processing for distributed physiological sensing arrays. The review provides a framework for choosing how channels share wiring, power and bandwidth, rather than treating sensor count alone as the measure of array capability.

Bioelectronics / Methods & fabrication / Longitudinal physiology

Advanced Functional Materials

Bio‐Derived Polyurethane Ionoelastomers With Hierarchical Dynamic Networks for Ultrawide‐Range Iontronic Pressure Sensing

Chen‐Yu Wang, Hai‐Sen Yang, Wen‐Tao Wang, Xue Feng, Xin‐Yu Lin, Jia‐Hao Guo, Ze‐Xu Yang, Ruo‐Yu Sun, Ke‐Zheng Chen, Tingrui Pan, Sheng‐Lin Qiao

Bio-derived polyurethane ionoelastomers use hierarchical dynamic networks for wide-range iontronic pressure sensing. The material strategy may inform the balance between sensing range and sensitivity in soft tactile devices. The network design may offer a materials route to balancing large deformation with pressure response; device-level calibration and durability remain important comparison points.

Wearables & e-skins

Advanced Functional Materials

Flexible Neuromorphic Softness Sensory System

Ruotao Yu, Jiarui Zhang, Qianbo Yu, Yu Cheng, Wentao Xu

A flexible neuromorphic system distinguishes softness. The approach offers a reference for array-level processing of tactile and tissue-mechanics signals. The potential connection to tissue assessment is the conversion of a softness-related response into a processed sensory output, rather than retaining only an unprocessed force signal.

Wearables & e-skins / Mechanics & resonators

Advanced Healthcare Materials

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Kunal P. Pednekar, Daan Vorselen, Jai Prakash

Spatiotemporal force mapping in three-dimensional spheroids reveals how macrophage–fibroblast interactions affect tumour mechanics. The method offers a reference for quantitative studies of tissue mechanics and the mechanical microenvironment. The three-dimensional model may help relate interactions between different cell populations to a changing mechanical environment, informing the interpretation of local force measurements.

Mechanics & resonators

Advanced Materials

Bridging Biosensing and Hardware‐Level Data Security With a Conjugated Radical Polymer

Hoyeon Lee, Jaehyoung Ko, Dinh Cung Tien Nguyen, Yeong Kwon Kim, Daeun Kim, Soo Jin Cho, Sung Gap Im, Byung Chul Jang, Byung Joon Moon, Yongho Joo

A conjugated radical polymer connects biosensing with hardware-level data security. The concept offers a potential route to secure encoding in distributed wearable or implantable nodes. For distributed biosensing, the potential relevance is the connection between material-level signal generation and secure information handling, rather than a separate security layer added after measurement.

Bioelectronics / Methods & fabrication

Advanced Materials

Minimally Invasive In Vivo Fabrication of Multiscale Biohybrid Systems

Zhixing Ge, Yuji Gao, Elgene Chng Junyuan, Truong‐Son Dinh Le, Lanfeng Liang, Yu Zhang, Chwee Teck Lim

Minimally invasive in vivo fabrication offers a material and integration route to multiscale biohybrid systems. The approach may inform in situ formation and delivery of complex implants. The in vivo construction concept may be useful when considering how to place or form a functional interface with limited surgical access; specific device applications need their own validation.

Bioelectronics / Methods & fabrication

Advanced Materials

Strain‐Insensitive Conductors for Stretchable Electronics

Tong Zheng, Shengxin Xiang, Jianqiang Gao, Qiongfeng Shi, Xinkai Xie, La Li, Guozhen Shen, Jun Wu

This work examines structural strategies for strain-insensitive conductors in stretchable electronics. These strategies are relevant to interconnect stability, fatigue and suppression of deformation-related readout changes. The design question is how to keep the conductor electrically stable while the surrounding structure stretches, a useful distinction from deliberately strain-sensitive sensing elements.

Wearables & e-skins / Methods & fabrication

Biosensors and Bioelectronics

Dual-MOF encapsulated smart gel electrolyte for plant-wearable electrochemical detection of organophosphate pesticides

Yue Cao, Yiru Sheng, Xinyu Weng, Yingzhen Zhuang, Ru Wu, Ruchuan Cao, Shichao Ding, Wenlei Zhu, Yang Zhou

A plant-wearable electrochemical patch uses acid-responsive ZIF-8 nanocontainers to separate an enzyme from its substrate until activation. A conformal MXene hydrogel supports leaf attachment. The reported phoxim detection limit is 2.8 ng/mL; the material-controlled activation method may inform other flexible biochemical sensors. The controlled separation and activation of reagents may be transferable to other wearable chemical interfaces where premature mixing would complicate measurement.

Wearables & e-skins / Methods & fabrication

IEEE Transactions on Biomedical Engineering

A Sensitive BLE-Enabled Wearable fNIRS Biosensor for Real-Time Monitoring and Mapping of Task-Evoked Oxygen Influxes During On-Screen Cognitive Tasks

Rajesh Mandal, Gayathri Sai Prabhakaran, Arjun V Kowshik, Bhargav Makam Balaji, Balaji Jayaprakash

A four-channel wearable fNIRS device combines optical acquisition with Bluetooth Low Energy transmission for cable-free hemodynamic recording. Vascular, breath-hold and cognitive tasks validate its responses. The work also proposes a task-evoked oxygenation metric, with potential relevance to wearable measurements of cognitive engagement. The combination of optical channels and wireless transmission may inform a practical balance between measurement coverage and wearable complexity during cognitive tasks.

Wearables & e-skins / Longitudinal physiology

IEEE Transactions on Biomedical Engineering

An Improved Fabrication Method for Flexible COC-Based Implantable Neural Probes with Reliability Validation

Taekyung Lee, Joowon Lee, Seoyoung Hwang, Jisung Kim, Sang Beom Jun, Changhoon Baek, Jongmo Seo

Flexible neural probes combine T-die-cast cyclic olefin copolymer films, femtosecond laser machining and iridium oxide electrodes. The study reports 681.04 ohms impedance at 1 kHz and insulation leakage below 1 nA after 320 days of accelerated soaking at 75 °C. These results concern fabrication and accelerated reliability, rather than long-term clinical validation. The extended soaking test offers a useful reliability reference, while the difference between accelerated conditions and chronic implantation remains important when comparing lifetimes.

Methods & fabrication / Bioelectronics

IEEE Transactions on Biomedical Engineering

Function-based Deep Learning Autoencoder for Passive Shimming in a Portable MRI Magnet with Enhanced Field Homogeneity

Jiannan Zhou, Xia Xiao, Guoquan Chen, Pengfei Zhao, Yanwei Pang, Zhenchang Wang

A self-supervised autoencoder optimizes the distribution of passive ferromagnetic shims in a portable MRI magnet. The study reports an improvement in field homogeneity from 4,873 to 547 ppm. The optimization method offers a transferable reference for magnetic-field design, although the demonstrated application is MRI. The learning-based distribution of magnetic material may offer ideas for field-shaping problems beyond MRI; the reported homogeneity improvement remains specific to the tested magnet.

Magnetic systems / Methods & fabrication

Microsystems & Nanoengineering

A fabrication-aware vectorized generative representation for topology optimization of path-defined MEMS microstructures

Gong-Zeng Liu, Lin-Feng Zhao, Jie Zhang, Xiang Liu, Yi-Meng Lv, Tian-Yu Geng, Zai-Fa Zhou

A vectorized design representation embeds linewidth, spacing and smoothness constraints into MEMS topology optimization. Reported examples reduce microheater temperature variation from 4.04% to 1.22% and increase microspring displacement by 30.6% with a 16.3% reduction in peak stress. Embedding process constraints in the representation may help reduce the gap between an optimized geometry and a microstructure that can actually be fabricated.

Methods & fabrication

Nano Letters

Unveiling the Creep Recovery Behavior of Pseudo-Free-Standing Polymer Thin Films for Wearable Electronics

Eun Sung Oh, Dong Jun Kim, Won Choi, Taek-Soo Kim

This study examines creep recovery in pseudo-free-standing polymer thin films. Its findings are relevant to long-term drift, fatigue and mechanical stability of wearable substrates and packaging. Understanding recovery after sustained deformation may help distinguish reversible mechanical effects from persistent baseline changes in thin-film wearable components.

Wearables & e-skins / Methods & fabrication

Nature

Fabric user interface can be worn on your sleeve — and machine-washed

Shanshan Yao

This Nature commentary discusses a machine-washable textile interface that integrates display, touch sensing and wireless interaction. The associated research article is also included in this edition. It offers perspective on integrating several electronic functions into a textile interface; device specifications and experimental evidence belong to the accompanying research paper.

Wearables & e-skins

Nature Nanotechnology

Millisecond phonon lifetimes in piezoelectric nanomechanical resonators

Oliver A. Hitchcock, Matthew P. Maksymowych, Kaveh Pezeshki, Takuma Makihara, Erik Szakiel, Chou-Wei Kiang, Daniel Rugar, Amir H. Safavi-Naeini

Surface repair after ion milling and shadow-mask metallization reduce losses in lithium-niobate nanomechanical resonators. The study reports phonon lifetimes up to 21 ms at 3.6 GHz and quality factors above 4 × 10⁸, with fabrication lessons for resonant sensors. The fabrication strategy may help identify which surface and electrode processes merit attention when optimizing resonant sensor losses; the reported lifetime concerns the stated resonator platform.

Mechanics & resonators / Methods & fabrication

Proceedings of the National Academy of Sciences

First-principles channel model and capacity-achieving transmission scheme in thermal noise backscatter links

Geneva Ecola, Jida Zhang, Joseph M. Kahn, Zerina Kapetanovic

A first-principles channel model and capacity-achieving scheme address backscatter transmission in thermal noise. The analysis is relevant to link budgets and decoding at low signal-to-noise ratios in passive wireless readout. The theoretical link analysis may help assess how passive readout architectures trade transmission performance against a weak received signal, before selecting a particular sensor implementation.

Methods & fabrication

Proceedings of the National Academy of Sciences

mechanoLight: A genetically encoded fluorescent biosensor for visualizing 5-HT2AR mechanotransduction in live cells

In-Yeop Baek, Hyunbin Kim, Duwan Kwon, Hahnbeom Park, Jihye Seong

The genetically encoded fluorescent biosensor mechanoLight visualizes 5-HT2AR mechanotransduction in living cells. The approach provides a reference for optical interrogation of biochemical and mechanical signal transduction. The relevance to biosensing lies in visualizing a mechanically triggered cellular pathway, which may complement measurements of tissue-level force or deformation.

Mechanics & resonators / Bioelectronics

Research Square - Nature Portfolio

An acoustic coupling fluid improves intraoperative ultrasound image quality during glioma surgery: Results of a Pivotal Multicenter Study (NCT04734444)

Francesco DiMeco, Massimiliano Del Bene, Giovanni Carone, Annica Piccardi, Jan Coburger, Andrej Steno, Rainer Ritz, Benjamin Sass, SonoClear® ACF Investigators

A prospective, nonrandomized five-centre study evaluates a tissue-mimicking acoustic coupling fluid during glioma surgery. Among 44 patients, 40 paired comparisons show improved ultrasound image ratings and reduced artefacts below the resection cavity. The reported improvement concerns image quality; benefits for resection extent or patient outcomes remain unproven. Acoustic-medium engineering may be useful for intraoperative sensing systems. Preprint; not peer reviewed. The work suggests that engineering the acoustic medium can complement hardware improvements, while the nonrandomized study design limits conclusions about clinical benefit.

Methods & fabrication / Bioelectronics

Research Square - Nature Portfolio

Intrinsic Vectorial Gradiometry via Quantum Control of a Spin-based Sensor

Jaime García Oliván, Pablo Acedo, Oliver T. Whaites, Jorge Casanova

Quantum-control sequences extract temporal and spatial magnetic-field derivatives from a single spin-based sensor. The proposed implementation combines nitrogen-vacancy diamond sensing, nuclear-spin memory and controlled motion. Numerical simulations explore magnetic-anomaly detection and neuronal action-potential sensing; these are not biological recording experiments. The approach may inform compact magnetic-gradient readout and background rejection for biosensing systems. Preprint; not peer reviewed. The gradiometric formulation may be relevant when a small local magnetic signal must be distinguished from background fields, with biological use still requiring experimental demonstration.

Magnetic systems / Methods & fabrication

Research Square - Nature Portfolio

Multiparametric quantification of dynamic force adaptation in living cells by atomic force microscopy

Hermann Schillers, Tristan Claus, Dominika Ciechańska

Time-Resolved Mechanical Response analysis uses constant-load atomic force microscopy to quantify bidirectional displacement, work, power and mechanical balance in living cells. Endothelial-cell experiments probe responses to cytoskeletal, mechanosensitive and inflammatory perturbations. The model-independent workflow uses conventional AFM hardware and may help distinguish dynamic force adaptation from static elasticity measurements when designing mechanobiological sensing experiments. Preprint; not peer reviewed. The emphasis on time-dependent mechanical response may be useful for sensing studies where adaptation and dissipation matter as much as a single stiffness value.

Mechanics & resonators / Methods & fabrication

Research Square - Nature Portfolio

Thermal-history encoding through ionic-state programming in a monolithic organic thermosynapse

Do Hwan Kim, Zhengyang Kong, Jin Han Kwon, Ji Hong Kim, Hanbin Choi, Jonghyun Yun, Seonghwan Yun, Hyeon Woo Yang, Hyun Joon Shin, So Young Kim, Yong Min Kim, Hong Chul Moon

A zwitterionic temperature-responsive gel enables an organic electrochemical transistor to encode thermal exposure through ionic-state programming. Heating regulates ion confinement and release, linking temperature history to retained device response. A robotic demonstration uses this state to control recontact and limit cumulative heating and drift in a colocated pressure sensor. The concept connects material memory with adaptive tactile interfaces. Preprint; not peer reviewed. The retained ionic state may offer a materials-based way to represent exposure history, which could complement wearable measurements that otherwise capture only an instantaneous condition.

Wearables & e-skins / Bioelectronics / Methods & fabrication

Science Advances

Bioinspired supramolecular thermistor for resolving subtle temperature variations

Yangtao Yu, Yahui Li, Dongyuan Zhang, Haoqi Han, Xinyu Ren, Kaiqi Gao, Haozhe Wen, Jiaxiang Wang, Zhiyuan Hu, Han Ren, Sicheng Chen, Ruiqing Ge, Yu Chang, Mingyi Chen, Hesheng Wang, Zhuoqing Yang, Yuanjin Zheng

A bioinspired supramolecular thermistor resolves subtle temperature changes. Its material design offers a reference for temperature channels and compensation in multimodal soft sensors. For multimodal sensing, the potential transfer is a temperature-sensitive channel that could be considered alongside mechanical measurements; performance under combined perturbations would need separate testing.

Wearables & e-skins

Science Advances

Extended field-of-view two-photon imaging in the deep brain of freely behaving mice using lightweight microfabricated corrective optics

Chiara Nardin, Andrea Sattin, Sebastiano Curreli, Giorgio Letti, Laura Maddalena, Leonardo Nacci, Tommaso Fellin

Lightweight microfabricated corrective optics extend the field of view for deep-brain two-photon imaging in freely behaving mice. The approach offers hardware-design lessons for readout during natural movement. The work may inform optical packaging for neural measurements that must preserve both access to deep structures and tolerance of natural movement.

Wireless implants / Methods & fabrication

Science Advances

Mechanoadaptive nanowire viscoplastic composites with strain-enhanced conductivity for reprocessable bioelectronic interfaces

Ran Huo, Shengyun Huang, Dixiang Gong, Xin Zhou, Heng Zhu, Pengyun Zhang, Hideaki Okuyama, Guangyu Bao, Xuan Li, Aram Bahmani, Lisa Martignetti, Zixin Zhang, Hongyu Hou, Changhong Cao, Yixun Cheng, Wei Gao, Dongling Ma, Nicole Y. K. Li-Jessen, Jianyu Li

Mechanoadaptive nanowire viscoplastic composites show strain-enhanced conductivity and can be reprocessed into bioelectronic interfaces. The work offers material-design ideas for electrodes and interconnects under repeated deformation. The combination of mechanical adaptation and recoverable processing may be relevant to soft interfaces that must maintain electrical continuity as their shape changes.

Wearables & e-skins / Bioelectronics

Science Advances

Ultrasound-driven electronically programmable microbubbles

Zhiyuan Zhang, Jinsong Zhang, Alyosha C. Molnar, Itai Cohen

Ultrasound-driven microbubbles with electronic programmability offer a route to remote acoustic actuation and local responses. The concept may inform wireless systems for access to deep tissue. The acoustic drive and electronic programmability suggest a route to separating remote energy delivery from local control; adapting the concept to tissue monitoring would require further validation.

Bioelectronics

bioRxiv · Bioengineering

Microrobot and Cellbot Locomotion in Confined Hydrogels and Cardiac Tissue Surfaces

Kirmizitas, F. C., Mallick, S., Cherukumilli, S., Lee, Z. D., Zhao, Y., Dutta, A., Liu, Y., Das, S.

This preprint compares magnetic microrobot and cellbot locomotion in dishes, hydrogels and ex vivo cardiac tissue. Rotating-field frequency, fibre orientation and cell adhesion affect trajectories and speed. The work has not been peer reviewed. The comparison may help separate the effects of the surrounding matrix from those of the moving body itself when designing magnetic transport through soft biological environments.

Magnetic systems

npj Flexible Electronics

Machine learning–driven structural optimization of zigzag silk fibroin ionic conductors for spatially resolved wearable motion detection

Yunhao Yang, Sijia Sun, Cheng Xu, Jing Ren, Shengjie Ling

A surrogate model trained on 3,000 zigzag silk-fibroin conductor geometries guides structural optimization. A ten-channel device retains spatial fingerprints during joint bending, with Spearman correlations of 0.75–0.84; the workflow may transfer to flexible-array design. The geometry-driven workflow may help preserve channel-specific motion information in a deformable array; transfer to another material system would require retraining or validation.

Wearables & e-skins / Methods & fabrication

Nature

Body-clock disruptions contribute to one in four cases of depression, suggests large study

Rachel Fieldhouse

This Nature news report discusses population-level associations between circadian disruption and depression. It provides context for longitudinal physiological monitoring rather than a new sensing technology. For sensor development, the relevance lies in linking repeated physiological measurements to longer-term disease patterns; the reported association should not be read as proof of an individual causal pathway.

Longitudinal physiology

Nature Communications

Author Correction: Coaxially printed magnetic mechanical electrical hybrid structures with actuation and sensing functionalities

Yuanxi Zhang, Chengfeng Pan, Pengfei Liu, Lelun Peng, Zhouming Liu, Yuanyuan Li, Qingyuan Wang, Tong Wu, Zhe Li, Carmel Majidi, Lelun Jiang

This author correction concerns printed magnetic–mechanical–electrical hybrid structures with combined actuation and sensing. It is retained as a correction, not as a report of new experimental results. Readers comparing device performance should consult the corrected original paper together with this notice; the correction itself does not establish an additional sensing or actuation result.

Magnetic systems

Neuron

Distinct patterns of whole-body coding in human motor cortex and posterior parietal cortex

Kelly Kadlec, Jorge Gamez, Tyson Aflalo, Charles Guan, Emily R Rosario, Kelsie Pejsa, Ausaf Bari, Nader Pouratian, Richard A Andersen

Single-neuron recordings in people with tetraplegia reveal different patterns of body-part representation in motor and posterior parietal cortex. The distinction offers adjacent context for the choice of neural recording sites and signals in brain–machine interfaces. The findings may help frame which cortical location to record from for a particular intended movement signal; this study concerns neural representation rather than a new implant fabrication process.

Bioelectronics

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